bioVidria Technology
The basis of bioVi
dria’s platform surface technology is a thin film of silica nanoparticles of uniform size. They spontaneously form silica colloidal crystals, which are porous media that are much more uniform and rugged than those of the polymers used for the last half century in biological analysi, including polyacrylamide and agarose gels, nitrocellulose films and nylon membranes. There are no products on the market for biological analysis that use porous silica collodial crystals.
The accompanying graphs highlight the key attributes to this surface technology that provides the significant benefits in genetic and proteomic research
efforts. Figure 1 illustrates the significant increase in fluorescence, relative to a flat surface, as the collodial crystal film increases in thickness. While the enhancement is the highest at the thicker coatings – upwards of 80x improvement in fluorescence – this parameter can be completely controlled to allow for particular research requirements. For the nd user, this provides tangible and considerable improvements in signal.
This increase in signal would not be useful if it was accompanied by a parallel increase in background noise. In Figure 2, a log scale indicates that across the various thicknesses of the collodial crystals, there is little to no increase in background noise as the signal or fluorescence increases.
These combined benefits provide a significant improvement over existing technologies and allows researchers actually to see images that were either entirely unobservable or simply to faint to see.